Abstract: This research uses 253 reference involving five fields of culture education, bio-medicine, economy trade, ecological environment and social management, analyzes the context of research development, evaluates the defects of the relationship between knowledge and ethics, and points out that expansion of research perspective, clarity of agencies, combination of qualitative and quantitative studies are the evolution trend of future researches. The perfect blend of knowledge and ethics deepens the level of consciousness of human mind; ethics constraints on the knowledge economy provide direction for the harmonious and healthy development of knowledge under ethical framework.