Abstract: In order to explore regional environment affected large enterprises and small & medium enterprises growth performance,used statistical data tested growth difference of China's industrial enterprises by the method of nuclear density estimation and quantile regression. The results showed that:Large enterprises and small & medium enterprises had a long-term polarization development trend; Natural resources and infrastructure environment,human resources environment,technology environment,business environment,political and law environment had influence on the growth of different types of enterprise,its effects in different percentile level were differences. Natural resources and infrastructure environment,business environment both had a significant positive influence on the growth of large enterprises and small & medium enterprises; Human resources environment,political and law environment had a significant positive influence on small & medium enterprises growth better than large enterprises; Technology environment had a significant positive influence on large enterprises growth better than small & medium enterprises.