Abstract: The spreading and acceptance of Yangming’s Xin school in Guanzhong Area is a not too concerned, less deeply researched but very valuable academic issue. Its experiences the debating and explaining in the early period, the thriving and fusing in the late Ming dynasty, the continuing and amending in the early Qing dynasty, the maintaining and finishing in the late Qing dynasty, showing the “Guan zhong mode” of the spreading and acceptance of Yangming’s Xin school: Firstly, it failed to replace Zhang Zai’s Guanxue and Cheng Zhu Neo-Confucianism’s leading position in the Guanzhong area; Secondly, it showed a parabolic propagation trend with no obvious fluctuations and small twists and turns; Thirdly, the theme is fusing Zhu zi Neo-Confucianism and Yangming’s Xin school. The fusion and interaction of Guan Xue and Yangming’s Xin school not only generates and updates Guan Xue, promoting Guan Xue to turn to Yangming’s Xin school, but promotes Yangming’s Xin school to achieve self-perfection and conversion and reveals the possible evolution direction of Yangming’s Xin school, which becomes a concrete and vivid case for us to explore the “localization” of Yangming’s Xin school.