Abstract: Cooperation among local governments is greatly instrumental in cross-regional synergy that is integral to China’s national economic mobilization efforts at present and in the future. Based on the analysis of the characteristics of cross-regional synergy mobilization in emergency resources, this paper dives into the choice of a coordination game model for cooperation among local governments, and studies the key elements and dynamic conditions of inter-governmental cooperation in the process of cross-regional emergency resource synergy when only two local governments are involved. In addition, a symmetric coordination game model has been built to analyze the selection strategy for cooperation between local governments under the conditions of unconstrained and restricted mechanisms. In this paper, three important factors that affect cooperation among local governments are concluded: the net benefits produced by local governments’ choice of cooperation, the influence of the central (superior) government, and the basis for cooperation among local governments.