Abstract: The paper introduced the characteristics of spatial layout systematically in four aspects, including its geography position, modality of regional growth pole, spatial form of city cluster and strategic themes. The regional growth pole’s groups’ differences were analyzed,according to Factor Analysis which was used to find the dimensionality of the regional differences and calculate the component score. This paper pointed out that three factors influence the development of these cities: hauling ability, input efficiency and industry structure and some conclusions were drawn. Firstly,Pudong Area and Shenzhen Area are developed, efficient and internationalized Reform Pilot Areas. Service industry is flourishing in these areas. They should be developed at an accelerated pace in the future. Secondly, Binhai Area has been developing rapidly where manufacture industry and many foreign capitals conglomerate. But efficient and modern industry structures should be built. Thirdly, Wuhan is the city which has the best development capacity in Wuhan cluster and Chang-Zhu-Tan cluster. It will be the major regional growth pole in the middle-area of China. Chengdu has been developing better than Chongqing in Cheng-Yu cluster. It is indispensable to enhance the modern industry system in Wuhan and Chengdu, and optimize the industrial structures of Chongqing, Changsha, Zhuzhou and Xiangtan. In the end, some directions were proposed for the future.