Abstract: Express enterprise distribution system is a super-network system with characteristics of multi-layers, multi-dimensions and multi-criteria, consisting of physical layer networks and management layer networks. As the operation unit of business management dimension sub-network in management layer network, transshipment center views efficiency maximization as its business objective. By regarding the delivery time as the edge weights, an efficiency-based optimization method for this super-network is analyzed in business management dimension, with the results showing that:(1) efficiency maximization of transshipment center can be obtained by suitable routing selecting and reasonable transportation means choice;(2) peak efficiency of express enterprise can be acquired only when all transshipment centers of it have achieved the highest efficiency.