Abstract: In order to improve the effectiveness of safety management in the enterprises, a study of how the “human-oriented” management affects safety performance is conducted. From the perspectives of management, a hypothesis relation between “human-oriented” management and safety performance is established through work stress as an intermediary benefit to explain the relevant impacts. Data were obtained from a survey among workers at the production line and at the basic level in eight electricity enterprises in Beijing, Yunnan, Jiangsu and Hebei. Four factors’(safety institution, training and education, communication system, psychology counseling effects) on safety performance were studied by using the SEM. Empirical analysis shows that: the operation stress, safety management stress and stress recognition connect “human-oriented” management and safety performance as a bridge; psychological counseling stands out most. The result of the study shows that “human-oriented” management is beneficial to boost enterprise safety performance. It is advised that efforts be made to promote safety performance in the areas of improving work atmosphere, advancing employees’capability of stress management, and optimizing enterprise policies.